Optical evodiamine derivatives: Asymmetric synthesis and antitumor activity was written by Li, Zhen-Gang;Dong, Guo-Qiang;Wang, Sheng-Zheng;Miao, Zhen-Yuan;Yao, Jian-Zhong;Zhang, Wan-Nian;Sheng, Chun-Quan. And the article was included in Chinese Chemical Letters in 2015.Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid This article mentions the following:
Evodiamine and its derivatives have an asym. center at the C13b position. Herein, isomers of evodiamine derivatives were obtained by straightforward asym. total synthesis. Their inhibitory activities toward topoisomerases I and II and their cytotoxicities in cancer cell lines were evaluated. All the four isomers exhibited good to excellent antitumor potency and the (S)-isomers were generally more active than the (R)-isomers. The binding modes of compound I with topoisomerases I and II were also clarified by mol. docking. In the experiment, the researchers used many compounds, for example, 2-Oxopiperidine-3-carboxylic acid (cas: 41888-21-5Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid).
2-Oxopiperidine-3-carboxylic acid (cas: 41888-21-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem