《Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents》 was written by Li, Gang; Huan, Yi; Yuan, Baokun; Wang, Jin; Jiang, Qian; Lin, Ziyun; Shen, Zhufang; Huang, Haihong. Computed Properties of C7H15NOThis research focused onxanthine derivative preparation GPR119 DPPIV targeting diabetes; DPP-IV; Dual ligands; GPR119; Merged pharmacophores; Xanthine derivatives. The article conveys some information:
A series of xanthine derivatives as potent dual ligands targeting DPP-IV and GPR119 was discovered through an approach of the merged pharmacophores of GPR119 agonists and DPP-IV inhibitor linagliptin. Systematic optimization of general structure 5 led to the identification of compound 20i with selective DPP-IV inhibition, good GPR119 agonism activity and favorable metabolic stability. Docking study was performed to elucidate the potent DPP-IV inhibition of 20i. Compound 20i may serve as a tool compound for further design of anti-diabetic drugs targeting both DPP-IV and GPR119. The experimental part of the paper was very detailed, including the reaction process of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKComputed Properties of C7H15NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem