Synthesis and antiproliferative activity of C- and N-terminal analogues of culicinin D was written by Li, Freda F.;Stubbing, Louise A.;Kavianinia, Iman;Abbattista, Maria R.;Harris, Paul W. R.;Smaill, Jeff B.;Patterson, Adam V.;Brimble, Margaret A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Computed Properties of C21H21NO4 The following contents are mentioned in the article:
Culicinin D, a 10 amino acid peptaibol containing several unusual residues, has been shown to exhibit potent anticancer activity. Previous work in our group towards developing a structure-activity relationship (SAR) for this peptaibol has concentrated on replacement of the synthetically challenging AHMOD and AMD residues, resulting in the discovery of analogs with equivalent or better potency and simplified synthesis. The SAR of this peptaibol is extended in this work by investigating the effect of the N-terminal lipid tail and C-terminal amino alc., revealing the key contribution of each of these moieties on antiproliferative activity in a panel of breast and lung cancer cell lines. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Computed Properties of C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Computed Properties of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem