Neutral Molecule Receptor Systems Using Ferrocene’s “Atomic Ball Bearing” Character as the Flexible Element was written by Li, Chensheng;Medina, Julio C.;Maguire, Glenn E. M.;Abel, Ernesto;Atwood, Jerry L.;Gokel, George W.. And the article was included in Journal of the American Chemical Society in 1997.Application of 15336-72-8 This article mentions the following:
Fourteen novel ferrocene derivatives were designed to serve as receptors for low mol. weight diamines. The compounds that were prepared and fully characterized possess two ferrocenedicarboxylic acid residues bridged by amide formation in their resp. 1′-positions by 4,4′-benzidinyl (15), 3,3′-dimethoxy-4,4′-benzidinyl (16), 2,7-fluorenyl (17), 3-methoxy-2,7-fluorenyl (18), 4-N-piperazinoanilinyl (19), N,N’-4,4′-bipiperdinyl (20; shown as I), and 4,13-diaza-18-crown-6 (21). In two cases, ferrocenecarboxylic acid was bridged by spacers attached using 1-methylene groups. The bridges in these cases were 4,13-diaza-18-crown-6 (22) and 1,5-diaminoanthraquinone (24). In a single case, ferrocenecarboxylic acid was bridged by 1,5-dicarbonylnaphthalene (25). In one addnl. case, the bridge was created by formation of an imine followed by hydrogenation, but both compounds proved to be relatively unstable. Attempts to increase solubility afforded the N-ethylated derivative of 15 and the derivative 27 having carboxamides in the 1′-positions. A solid state structure of the di-Et ester of 20 confirms the design criteria. Complexation constants were determined in THF-d8 or CDCl3 for combinations of receptors 18, 19, and 20 with 4-aminopyridine, N,N,N’,N’-tetramethylethylenediamine, N,N,N’,N’-tetramethylpropylenediamine, DABCO, 3-propyladenine, and benzimidazole and were in the range 102-104. The anticipated complexation mechanism for 20 with N,N,N’,N’-tetramethylpropylenediamine was confirmed by observation of an NOE between host and guest. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8Application of 15336-72-8).
4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application of 15336-72-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem