Stereo-complementary bioreduction of saturated N-heterocyclic ketones was written by Li, Chao;Liu, Yan;Pei, Xiao-Qiong;Wu, Zhong-Liu. And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2017.COA of Formula: C13H17NO3 This article mentions the following:
The asym. bioreduction of several saturated N-heterocyclic ketones such as 1-benzylpyrrolidin-3-one, 1-benzylpiperidin-3-one, 1-benzylazepan-3-one, etc. is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcs. such as 1-benzylpyrrolidin-3-ol, 1-benzylpiperidin-3-ol, 1-benzylazepan-3-ol, etc. resp. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent and achieves >99% ee in the majority of cases for both enantiomers. In the experiment, the researchers used many compounds, for example, Benzyl 3-hydroxypiperidine-1-carboxylate (cas: 95798-22-4COA of Formula: C13H17NO3).
Benzyl 3-hydroxypiperidine-1-carboxylate (cas: 95798-22-4) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.COA of Formula: C13H17NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem