Recently I am researching about RHO KINASE INHIBITORS; CELL-MIGRATION; HEPATOCELLULAR-CARCINOMA; AMEBOID INVASIVENESS; THERAPEUTIC TARGET; MYOSIN-II; GTPASES; METASTASIS; ACTIVATION; INVASION, Saw an article supported by the Ministry of Education, Youth and Sports, Czech Republic (National Program of Sustainability I) [LO1204, LO1304]; Ministry of Education, Youth and Sports, Czech Republic (project BIOCEV-FAR from National Program of Sustainability II) [LQ1604]; Ministry of Education, Youth and Sports, Czech Republic (project BIOCEV) [CZ. 1.05/1.1.00/02.0109]; Czech Grant AgencyGrant Agency of the Czech Republic [17-14007S, 15-17419S]; Palacky University [IGA_PrF_2018_006]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Name: 1,4-Dioxa-8-azaspiro[4.5]decane
Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.
Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M or send Email.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem