Leighty, Matthew W.; Georg, Gunda I. published the artcile< Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A>, Related Products of 149518-50-3, the main research area is boehmeriasin A alkaloid enantioselective synthesis anticancer cytotoxicity.
Both enantiomers of boehmeriasin A were synthesized in seven steps each using a chiral pool approach. Key steps in the syntheses were a one-flask, two-step protocol to generate the quinolizine core and a C-H functionalization reaction between tetrahydroquinolizinones and an aryltrifluoroborate. The natural product (R)-boehmeriasin A (I) demonstrated potent cytotoxicity against several cancer cell lines, whereas the unnatural (+)-(S)-isomer was significantly less potent.
ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 149518-50-3 belongs to class piperidines, and the molecular formula is C12H21NO4, Related Products of 149518-50-3.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem