Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Name: 4-Piperidinol.
Lei, Hongrui;Wang, Xinyu;Zhao, Guolong;Li, Tong;Cui, Youbao;Wu, Huinan;Yang, Jing;Jiang, Nan;Zhai, Xin research published 《 Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors》, the research content is summarized as follows. Aiming to track the potential antitumor effect of novel allosteric autotaxin (ATX) inhibitors, a hybrid strategy was utilized by merging ATX inhibitors PF-8380 and GLPG1690, while the piperazinyl group in GLPG1690 was replaced with benzene ring to furnish imidazo[1,2-a]pyridine derivatives I [R1 = 3,5-diCl, 4-CF3, 3,4-di-F; R2 = L-Prolinol, 4-hydroxyethylpiperazinyl, morpholine, etc.; R3 = CH2, C(O); X = O, N]. Based on ATX enzymic assay, further changed the substituents within benzyl carbamate moiety and tuned the carbamate linker to urea group. Delightfully, compound I [R1 = 3,5-diCl, R2 = 4-hydroxyethylpiperazinyl] was identified as the optimal ATX inhibitor with an IC50 value of 3.4 nM. Compound I [R1 = 3,5-diCl, R2 = 4-hydroxyethylpiperazinyl] exerted the most impressive antitumor effects, especially on Hep3B (0.58μM) and RAW264.7 (0.63μM) cell lines highly expressing ATX mRNA. Moreover, compound I [R1 = 3,5-diCl, R2 = 4-hydroxyethylpiperazinyl] could dose-dependently suppress the RAW264.7 cell migration rate in wound healing assay and significantly inhibit RAW264.7 cell colony formation. Meanwhile, compound I [R1 = 3,5-diCl, R2 = 4-hydroxyethylpiperazinyl] was capable of inducing weak to moderate apoptosis and achieved notable G2 phase arrest on RAW264.7 cells. Compound I [R1 = 3,5-diCl, R2 = 4-hydroxyethylpiperazinyl] may serve as a novel lead to probe possible role of ATX allosteric inhibitors in tumor diseases.
Name: 4-Piperidinol, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem