Safety of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylateOn September 25, 2006 ,《Asymmetric hydrogenation of pyridines: enantioselective synthesis of nipecotic acid derivatives》 was published in European Journal of Organic Chemistry. The article was written by Lei, Aiwen; Chen, Mao; He, Minsheng; Zhang, Xumu. The article contains the following contents:
An asym. hydrogenation process of 3-substituted pyridine derivatives has been developed with the use of a Rh-TangPhos complex as the catalyst. The whole process consists of an efficient partial hydrogenation of nicotinate and a subsequent highly enantioselective, Rh-catalyzed, homogeneous hydrogenation. A series of chiral nipecotic acid derivatives have been synthesized.(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4Safety of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate) was used in this study.
(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Safety of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem