In 1974,Jerusalem Symposia on Quantum Chemistry and Biochemistry included an article by Lambrecht, G.; Mutschler, E.. Formula: C8H15NO2. The article was titled 《Conformational isomerism in drug action. Does the free energy of binding induce the pharmacophoric conformation of semirigid muscarinic agonists》. The information in the text is summarized as follows:
3-Acetoxyquinuclidine (I) [827-61-2] and N-methyl-3-acetoxypiperidine [6659-33-2] had slightly greater guinea pig ileum contracting activity than acetylcholine [51-84-3]. The activity of dihydroarecoline [1690-72-8] was 513 times less than that of acetylcholine and 39 times less than quinuclidine derivatives I quaternary ammonium salt was 200 times less active than I. Methylquinuclidine-3-carboxylate [38206-86-9] was 40 times more active than its quaternary ammonium salt. On the other hand, the piperidine derivatives showed a slight increase in activity upon quaternary salt formation. The results are discussed in relation to conformational isomerism. In the part of experimental materials, we found many familiar compounds, such as Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Formula: C8H15NO2)
Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Formula: C8H15NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem