Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation was written by Kurahashi, Kei;Yamaoka, Yousuke;Takemoto, Yoshiji;Takasu, Kiyosei. And the article was included in Reaction Chemistry & Engineering in 2018.Computed Properties of C12H15NO3S This article mentions the following:
A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf2NH-amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etherification-(2 + 2) cycloaddition reaction were demonstrated. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Computed Properties of C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem