In 2015,Kumar, Sunil; Pathania, Anoop S.; Satti, Naresh K.; Dutt, Parbhu; Sharma, Neha; Mallik, Fayaz A.; Ali, Asif published 《Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition derivatives depicting cytotoxic potential》.European Journal of Medicinal Chemistry published the findings.HPLC of Formula: 622-26-4 The information in the text is summarized as follows:
Here we report the design, synthesis and lead optimization of hydroxychavicol (I) a high yielding metabolite ubiquitously present in the Piper betel leaves with the significant cytotoxic activity. This is the first report to describe the synthetic strategies of two distinct series of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition Furthermore, all the synthesized derivatives along with parent compound were evaluated for their in-vitro cytotoxic and antiproliferative potential in several distinct cancers cell lines. Among all, the Mannich reaction derived mols., e.g., II, displayed more potent cytotoxic activities with IC50 value in a range from 3 to 9 μM, which were 7-10 fold more potent than I against five human cancer cell lines viz. HL-60, Mia PaCa-2, MCF-7, HEP G2 and SK-N-SH. Our results describe an efficient synthetic approach used to evaluate the structure activity relationship of I and its derivative in search of potential new anticancer agents. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4HPLC of Formula: 622-26-4)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.HPLC of Formula: 622-26-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem