Electric Literature of C7H15NOIn 2016 ,《Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads》 appeared in Journal of Enzyme Inhibition and Medicinal Chemistry. The author of the article were Krasavin, Mikhail; Mujumdar, Prashant; Parchinsky, Vladislav; Vinogradova, Tatiana; Manicheva, Olga; Dogonadze, Marine. The article conveys some information:
A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald-Hartwig-type imidazoline arylation chem. developed earlier. Compounds were tested for biol. activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Electric Literature of C7H15NO)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKElectric Literature of C7H15NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem