Anaphylaxis to the first dose of mRNA SARS-CoV-2 vaccines: Don’t give up on the second dose! was written by Krantz, Matthew S.;Bruusgaard-Mouritsen, Maria A.;Koo, Grace;Phillips, Elizabeth J.;Stone, Cosby A. Jr;Garvey, Lene H.. And the article was included in Allergy (Oxford, United Kingdom) in 2021.Product Details of 83799-24-0 The following contents are mentioned in the article:
He vaccination program. two specialized allergy clinics (Nashville, USA, and Gentofte, Denmark) evaluated healthcare workforce members referred forpotential immediate, allergic reactions to the first dose of the PfizerBioNTech SARS-CoV-2 mRNA vaccine, with 13/23,035 (0.06%) and 34/54,567 (0.06%) of vaccinated healthcare workers being referred, resp. Of these 47 total patients referred for potential immediate, allergic reactions, 39 had histories of mild reactions and 8 had histories consistent with anaphylaxis to the first dose of the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine. All 8 went on to have an in-clinic observed second dose administration. Patient demographics, first-dose reaction history, polyethylene glycol (PEG) skin testing, and second dose administration outcome were evaluated. A serum tryptase was obtained in 5/8 patients within the appropriate 30-90 min time frame of their first-dose reaction and none were elevated. The lack of tryptase elevation during suspected first dose anaphylaxis, neg. PEG testing, and observed tolerance of the second dose do not support an IgE-mediated mechanism. Patients who demonstrate an IgE-mediated allergy to PEG would not fall into this category. Although we are still learning about the protective correlates of SARS-CoV-2 immunity, the second dose of the mRNA vaccines is associated with enhanced neutralizing antibody and T-cell responses, suggesting that it could be necessary for a more effective and durable immune response. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Product Details of 83799-24-0).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Product Details of 83799-24-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem