Kralj, Ana; Kurt, Elif; Tschammer, Nuska; Heinrich, Markus R. published an article in 2014, the title of the article was Synthesis and Biological Evaluation of Biphenyl Amides That Modulate the US28 Receptor.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:
To prepare and biol. evaluate 38 new potential US28 allosteric modulators were designed and the synthesis of the target compounds was achieved by the authors by a straightforward synthetic route involving a radical arylation. The study was based on a former lead structure but with the dihydroisoquinolinone moiety replaced by substituted biphenyl compounds The investigation of structure-activity relationships among the new biphenyl-derived ligands led to a preliminary pharmacophore model and the discovery of four promising candidates with full inverse agonist properties. The title compounds thus formed included a decanamide derivative (I) and related substances. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to biaryl biphenyl amide preparation antiviral agent viral infection, us28 receptor, amides, biphenyls, human cytomegalovirus, inverse agonism, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem