Koskinen, Ari published the artcileNovel applications of the modified Polonovski reaction. III. Regiospecific functionalization of carbon atoms α to heterocyclic nitrogen, Recommanded Product: Methyl 1-methylpiperidine-2-carboxylate, the main research area is Polonovski reaction piperidine carboxylate; nitrile piperidine.
A nitrile substituent was introduced at the exocyclic α C atom of the piperidine N, making the center either nucleo- or electrophilic in subsequent transformations. Piperidineacetates I (R1 = Me, Et, Ph, R2 = R3 = H; R1 = R2 = Me, R3 = H; R1 = Me, R2 = H, R3 = Et, Δ3) and II (R4 = CO2Me) were oxidized and the product converted via a modified Polonovski reaction [(F3CCO)2O instead of Ac2O] to the cyano compounds III and II (R4 = cyano), as well as IV and V (R4 = cyano). The generality of the method, along with the ease of operation, high yields, and regiospecificity, make this reaction highly versatile for synthetic purposes.
Tetrahedron published new progress about Polonovski fragmentation. 1690-74-0 belongs to class piperidines, name is Methyl 1-methylpiperidine-2-carboxylate, and the molecular formula is C8H15NO2, Recommanded Product: Methyl 1-methylpiperidine-2-carboxylate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem