Thin-layer chromatography of lactones, lactams, and thiolactones was written by Korte, Friedhelm;Vogel, Juergen. And the article was included in Journal of Chromatography in 1962.Quality Control of 1-Acetylpiperidin-2-one This article mentions the following:
These compounds are separated on thin layers of silica gel G with iso-Pr2O, 80:20 iso-Pr2O:EtOAc or 20:80 or 60:40 iso-Pr2O:isooctane as solvent systems. Lactones were detected by conversion to their hydroxamates, which were sprayed with HOAc and 10% aqueous FeCl3 to give brown spots. Lactams were detected with Dragendorff reagent; thiolactones were split with NaOH, and the resulting SH groups colored with Na nitroprusside. Rf values are tabulated for numerous compounds of these classes with 3 solvent systems. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Quality Control of 1-Acetylpiperidin-2-one).
1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem