Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi was written by Koovits, Paul J.;Dessoy, Marco A.;Matheeussen, An;Maes, Louis;Caljon, Guy;Mowbray, Charles E.;Kratz, Jadel M.;Dias, Luiz C.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.COA of Formula: C12H21NO3 This article mentions the following:
The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “Chagas box” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery. In the experiment, the researchers used many compounds, for example, tert-Butyl 3-acetylpiperidine-1-carboxylate (cas: 858643-92-2COA of Formula: C12H21NO3).
tert-Butyl 3-acetylpiperidine-1-carboxylate (cas: 858643-92-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C12H21NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem