Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors was written by Komiya, Masafumi;Asano, Shigehiro;Koike, Nobuyuki;Koga, Erina;Igarashi, Junetsu;Nakatani, Shogo;Isobe, Yoshiaki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Product Details of 4045-22-1 This article mentions the following:
A series of novel 2-substituted-5-hydroxyindoles were synthesized and evaluated for their inhibitory activity against CaMKII. Structure and activity relationship results indicated that potent inhibitory activity could be achieved by modification at the para-position of the Ph ring of the high throughput screening hit compound I. Among the prepared compounds, we identified II as a novel CaMKII inhibitor with an activity stronger than that of KN-93, a known CaMKII inhibitor. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Product Details of 4045-22-1).
1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Product Details of 4045-22-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem