Quality Control of Cis-piperidine-2,6-dicarboxylic acidOn November 30, 1985 ,《The characterization of the specific binding of [3H]-N-acetylaspartylglutamate to rat brain membranes》 appeared in Journal of Neuroscience. The author of the article were Koller, Kerry J.; Coyle, Joseph T.. The article conveys some information:
3H-labeled N-acetylaspartylglutamate (NAAG) [3106-85-2] bound saturably and reversibly to rat brain crude synaptosomal membranes. Optimal binding occurred in Tris-HCl buffer, pH 7.2, at 37°, using previously frozen, preincubated membranes. Saturation experiments revealed an apparent dissociation constant of 383 nm and a Bmax of 31 pmol/mg protein. [3H]NAAG specific binding was displaceable by serine-O-sulfate [626-69-7], quisqualate [52809-07-1], ibotenate [2552-55-8], and glutamate [56-86-0], with Ki values in the nanomolar range, whereas the amino-phosphono analogs displaced [3H]NAAG in the micromolar range. No specific binding was found in peripheral tissues. Within the central nervous system, the thalamus exhibited the greatest amount of binding, whereas binding was lowest in cortex. Ca2+ enhanced the specific binding, whereas Na+ caused a concentration-dependent inhibition. It appears that [3H]NAAG labels an acidic amino acid receptor site designated A-4, which recognizes the antagonist, 2-amino-4-phosphonobutyric acid, and this receptor may mediate the neurophysiol. effects of endogenous NAAG. After reading the article, we found that the author used Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Quality Control of Cis-piperidine-2,6-dicarboxylic acid)
Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Quality Control of Cis-piperidine-2,6-dicarboxylic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem