Kirk, R. published the artcileRational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2, Application In Synthesis of 73874-95-0, the main research area is tricyclic DNA gyrase topoisomerase inhibitor antibacterial agent pharmacokinetics.
Building on our previously-reported novel tricyclic topoisomerase inhibitors (NTTIs), we disclose the discovery of REDX07965, which has an MIC90 of 0.5 μg mL-1 against Staphylococcus aureus, favorable in vitro pharmacokinetic properties, selectivity vs. human topoisomerase II and an acceptable toxicity profile. The results herein validate a rational design approach to address the urgent unmet medical need for novel antibiotics.
RSC Medicinal Chemistry published new progress about Antibacterial agents. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Application In Synthesis of 73874-95-0.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem