Recommanded Product: 59234-40-1On October 31, 1982 ,《The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech, and horseshoe crab and on crab neuromuscular junction》 was published in Comparative Biochemistry and Physiology, C: Comparative Pharmacology. The article was written by King, D. J.; McBain, Anne E.; Jais, M. Mat; Roberts, C. Jane; Collins, J. F.; Wheal, H. V.; Walker, R. J.. The article contains the following contents:
The 2,3- [46026-75-9], 2,4- [84211-45-0], 2,5- [84619-48-7], and 2,6-piperidine dicarboxylates [59234-40-1] were devoid of direct or indirect effects of the Helix neuron; the 2,5-analog mimicked the actions of L-glutamate (I) [56-86-0] on Limulus neurons, and these were inhibited by I. All 4 piperidines mimicked the actions of I on Hirudo and rat neurons and Eupagurus muscle. All were weak agonists on rat neurons, whereas on Hirudo neurons the 2,5-analog was the most potent; on the Eupagurus muscle the 2,3- and 2,6-analogs were the most potent. All 4 piperidines potentiated the action of I on rat and Hirudo neurons and on Eupagurus leg muscle and of muscle excitatory junction potentials. Thus, there are probably differences between I receptors used in the study, and the preferred conformation for I on crab leg muscle may be the partially folded one and that for Hirudo neurons is more extended. The experimental part of the paper was very detailed, including the reaction process of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Recommanded Product: 59234-40-1)
Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 59234-40-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem