Kelso, Geoffrey F. published the artcileA Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic, Computed Properties of 219543-09-6, the publication is Chemistry & Biology (Oxford, United Kingdom) (2012), 19(10), 1237-1246, database is CAplus and MEDLINE.
Superoxide (O2l-) is the proximal mitochondrial reactive oxygen species underlying pathol. and redox signaling. This central role prioritizes development of a mitochondria-targeted reagent selective for controlling O2l–. We have conjugated a mitochondria-targeting triphenylphosphonium (TPP) cation to a O2l–-selective pentaaza macrocyclic Mn(II) superoxide dismutase (SOD) mimetic to make MitoSOD, a mitochondria-targeted SOD mimetic. MitoSOD showed rapid and extensive membrane potential-dependent uptake into mitochondria without loss of Mn and retained SOD activity. Pulse radiolysis measurements confirmed that MitoSOD was a very effective catalytic SOD mimetic. MitoSOD also catalyzes the ascorbate-dependent reduction of O2l–. The combination of mitochondrial uptake and O2l– scavenging by MitoSOD decreased inactivation of the matrix enzyme aconitase caused by O2l–. MitoSOD is an effective mitochondria-targeted macrocyclic SOD mimetic that selectively protects mitochondria from O2l– damage.
Chemistry & Biology (Oxford, United Kingdom) published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Computed Properties of 219543-09-6.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem