Karicherla, Venumanikanta published the artcileA Simple and Commercially Viable Process for Improved Yields of Metopimazine, a Dopamine D2-Receptor Antagonist, Category: piperidines, the publication is Organic Process Research & Development (2017), 21(5), 720-731, database is CAplus.
An efficient, practical, and com. viable manufacturing process was developed with ≥99.7% purity and 31% overall yield (including four chem. reactions and one recrystallization) for an active pharmaceutical ingredient, called Metopimazine I, an antiemetic drug used to prevent emesis during chemotherapy. The development of two in situ, one-pot methods in the present synthetic route helped to improve the overall yield of I (31%) compared with earlier reports (<15%). For the first time, characterization data of API I, intermediates, and also possible impurities are presented. The key process issues and challenges were addressed effectively and achieved successfully.
Organic Process Research & Development published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Category: piperidines.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem