Kang, Dongwei et al. published their research in Journal of Medicinal Chemistry in 2017 | CAS: 934536-10-4

tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate (cas: 934536-10-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Name: tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants was written by Kang, Dongwei;Fang, Zengjun;Huang, Boshi;Lu, Xueyi;Zhang, Heng;Xu, Haoran;Huo, Zhipeng;Zhou, Zhongxia;Yu, Zhao;Meng, Qing;Wu, Gaochan;Ding, Xiao;Tian, Ye;Daelemans, Dirk;De Clercq, Erik;Pannecouque, Christophe;Zhan, Peng;Liu, Xinyong. And the article was included in Journal of Medicinal Chemistry in 2017.Name: tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate This article mentions the following:

This work follows on from our initial discovery of a series of piperidine-substituted thiophene[3,2-d]pyrimidine HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) (J. Med. Chem. 2016, 59, 7991-8007). In the present study, we designed, synthesized, and biol. tested several series of new derivatives in order to investigate previously unexplored chem. space. Some of the synthesized compounds displayed single-digit nanomolar anti-HIV potencies against wild-type (WT) virus and a panel of NNRTI-resistant mutant viruses in MT-4 cells. I was exceptionally potent against the whole viral panel, affording 3-4-fold enhancement of in vitro antiviral potency against WT, L100I, K103N, Y181C, Y188L, E138K, and K103N+Y181C and 10-fold enhancement against F227L+V106A relative to the reference drug etravirine (ETV) in the same cellular assay. The structure-activity relationships, pharmacokinetics, acute toxicity, and cardiotoxicity were also examined Overall, the results indicate that I is a promising new drug candidate for treatment of HIV-1 infection. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate (cas: 934536-10-4Name: tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate).

tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate (cas: 934536-10-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Name: tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem