Synthesis, characterization and antimicrobial activity of substituted Tetrahydrothieno [2,3-c]pyridin-2-yl) Schiff base derivatives was written by Kalaria, Rushit;Odedara, R. J.;Dave, R. S.;Rajyaguru, Chetana;Upadhyay, Jatin J.. And the article was included in Journal of Applied Technology in Environmental Sanitation in 2012.Reference of 33439-27-9 This article mentions the following:
As a part of systematic investigation of synthesis, characterization and biol. activity of several new substituted Tetrahydrothieno [2,3-c]pyridin-2-yl Schiff base derivatives, (1a-1k) have been synthesized by well known chem. reaction of one active methylene containing moiety with a carbonyl function and Sulfur powder to give 2-Amino thiophene ring system followed by derivatization of amino into Schiff base using different aromatic aldehydes. The structures of all the synthesized compounds have been determined by their spectral and micro anal. data. All the compounds have been evaluated for their antibacterial activity against Gram Pos. bacteria like Staphylococcus aureus, Bacillus subtilis and Gram Neg. bacteria like Escherichia coli, Salmonella paratyphi B and they were also evaluated for antifungal activity against Candida albicans and Aspergillus niger at different concentrations Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Reference of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Reference of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem