In 1971,European Journal of Pharmacology included an article by Jung, Annemarie; Luellmann, Heinz; Ziegler, Albrecht. Electric Literature of C8H15NO2. The article was titled 《Attempt to correlate kinetic data of the drug receptor interaction with the chemical structures of cholinomimetic agents》. The information in the text is summarized as follows:
The chem. structures of cholinomimetic agents, such as acetylcholine (I) [51-84-3]; carbachol [51-83-2]; muscarine [300-54-9]; different esters of secondary, tertiary, or quaternary arecaidines or Δ3-pyrrolinecarboxylic acids; and the acetates of pyrrolidinol and pyrrolidinecarbinol, and their association and dissociation rate constants could be used to estimate their ability to bind with the receptor sites of isolated guinea pig atria. The ability to bind, as well as the kinetic constants, was dependant on the number of C-atoms at the N, the length of the ester side chain, the conformation for the heterocyclic ring system, and the position of the ester group. The influence of structural characteristics of the cholinergics on their properties was different from that on the parameters that determine their binding ability. The results came from multiple reactions, including the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Electric Literature of C8H15NO2)
Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Electric Literature of C8H15NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem