Jost, Micha et al. published their research in Chemistry & Biodiversity in 2007 | CAS: 86069-86-5

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Synthesis and structural and biological studies of efrapeptin C analogues was written by Jost, Micha;Weigelt, Sven;Huber, Thomas;Majer, Zsuzsanna;Greie, Joerg-Christian;Altendorf, Karlheinz;Sewald, Norbert. And the article was included in Chemistry & Biodiversity in 2007.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

A series of analogs of efrapeptin C, with variations in the central tripeptide epitope Leu-β-Ala-Gly (positions 6-8), were prepared by a combination of solid- and solution-phase peptide syntheses. The conformations of the modified compounds (Xaa6-Xaa7-Xaa8 = Leu-Gly-βAla, β-Ala-Leu-Gly, β3HLeu-Gly-Gly, Leu-β3-HPhe-Gly, Leu-Aib-Gly) were investigated by circular-dichroism (CD) spectroscopy to differentiate between 310– and α-helical secondary structures. The inhibitory activities of the new compounds towards F1-ATPase from E. coli were determined Threee modified congeners were less active by one order of magnitude compared to efrapeptin C (Ki 10 μM), and one was completely inactive. Our experiments demonstrate that the flexible, central tripeptide epitope, comprising positions 6-8 in efrapeptin C, is crucial for mol. recognition, even slight sequence modifications being hardly tolerated. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem