Jose, Gilish published the artcileNew polyfunctional imidazo[4,5-C]pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation, Related Products of piperidines, the publication is European Journal of Medicinal Chemistry (2014), 288-297, database is CAplus and MEDLINE.
New antimicrobial agents, imidazo[4,5-c]pyridine derivatives were synthesized. The authors have developed a new synthetic protocol for the final reaction, an efficient microwave-assisted synthesis of imidazo[4,5-c]pyridines from substituted 3,4-diaminopyridine and carboxylic acids in presence of DBU mediated by T3P. The chem. structures of the new compounds were characterized by IR, 1H NMR, 13C NMR, mass spectral anal. and elemental anal. In addition, single crystal x-ray diffraction also was recorded for compound 1-(7-(3-Fluorophenyl)-2-(phenoxymethyl)-1H-imidazo[4,5c]pyridin-4-yl)piperidine-3-carbonitrile. The in vitro antimicrobial activities of the compounds were conducted against various Gram-neg., Gram-pos. bacteria and fungi. Amongst the tested, seven compounds displayed promising antimicrobial activity. The mol. docking of GlcN-6-P synthase with newly synthesized compounds was carried out.
European Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Related Products of piperidines.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem