Synthesis and Application of N-Tosyl Piperidinyl-Containing α-Aminophosphonates was written by Jiang, Zhifu;Zhao, Jian;Gao, Beibei;Chen, Shuo;Qu, Wenyan;Mei, Xiangdong;Rui, Changhui;Ning, Jun;She, Dongmei. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2013.Category: piperidines This article mentions the following:
A series of novel (4′-tosyl) piperidin-4-yl containing α-aminophosphonates were synthesized by a one-pot reaction, efficiently catalyzed by magnesium perchlorate, under solvent-free conditions from 1-tosylpiperidin-4-one, substituted aromatic amines, and di-Et phosphite (DEP). The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, 31P NMR, and HRMS spectroscopy. A single-crystal X-ray structure of di-Et 4-(2-chlorophenyl) amino-1-(4′-methylbezenesulfonyl) piperidin-4-yl-phosphonate was obtained, and some of the title compounds displayed insecticidal activities against Plutella xylostella. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Category: piperidines).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem