On January 9, 2020, Ji, Nan; Mainolfi, Nello; Weiss, Matthew published a patent.Synthetic Route of 1251006-64-0 The title of the patent was Preparation of novel bifunctional compounds as MerTK degraders and uses thereof. And the patent contained the following:
The present invention provides compounds I [TAMBM is an TAM receptor kinase binding moiety; L is a bivalent moiety that connects TAMBM to DIM; and DIM is a degradation inducing moiety selected from LBM, a lysine mimetic, and H] or pharmaceutically acceptable salts thereof, compositions thereof, and methods of using the same. E.g., a multi-step synthesis of trans-II, starting from Et 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate, was described. Exemplified compounds I were tested for MerTK degradation in vitro (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Synthetic Route of 1251006-64-0
The Article related to bifunctional compound preparation mertk degrader, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1251006-64-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem