Jevtic, Ivana I. et al. published their research in Molecules in 2020 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C4H12Cl2N2

Newly synthesized fluorinated cinnamylpiperazines possessing low in vitro MAO-B binding was written by Jevtic, Ivana I.;Lai, Thu Hang;Penjisevic, Jelena Z.;Dukic-Stefanovic, Sladjana;Andric, Deana B.;Brust, Peter;Kostic-Rajacic, Sladjana V.;Teodoro, Rodrigo. And the article was included in Molecules in 2020.COA of Formula: C4H12Cl2N2 This article mentions the following:

Herein, the synthesis and pharmacol. evaluation of ten novel fluorinated cinnamylpiperazines I (R = 2-fluorophenyl, phenyl; R1 = (4-fluorophenyl)carbonyl, 2-fluoropyridin-3-yl, 6-fluoropyridin-2-yl, etc.)as potential monoamine oxidase B (MAO-B) ligands were reported. The designed derivatives I consist of either cinnamyl or 2-fluorocinnamyl moieties connected to 2-fluoropyridylpiperazines. The three-step synthesis starting from com. available tert-Bu piperazine-1-carboxylate afforded the final products I in overall yields between 9% and 29%. An in vitro competitive binding assay using l-[3H]Deprenyl as radioligand was developed and the MAO-B binding affinities of the synthesized derivatives I were assessed. Docking studies revealed that the compounds I were stabilized in both MAO-B entrance and substrate cavities, thus resembling the binding pose of l-Deprenyl. Although the results revealed that the novel fluorinated cinnamylpiperazines I do not possess sufficient MAO-B binding affinity to be eligible as positron emission tomog. (PET) agents, the herein developed binding assay and the insights gained within our docking studies will certainly pave the way for further development of MAO-B ligands. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3COA of Formula: C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics