In 2014,Ivashchenko, A. V.; Yamanushkin, P. M.; Mit’kin, O. D.; Kisil, V. M.; Korzinov, O. M.; Vedenskii, V. Yu.; Leneva, I. A.; Bulanova, E. A.; Bychko, V. V.; Okun, I. M. published 《Synthesis and Antiviral Activity of Ethyl 1,2-dimethyl-5-Hydroxy-1H-Indole-3-carboxylates and Their Derivatives》.Pharmaceutical Chemistry Journal published the findings.Category: piperidines The information in the text is summarized as follows:
New substituted Et 5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylates and 7,8-dimethyl-1,2,3,7-tetrahydro[1,3]oxazino[5,6-e]indole-9-carboxylates including arbidol analogs in addition to 6-hydroxy-1-methyl-7-pyridin-3-yl-4,5-dihydropyrrolo[4,3,2-de]isoquinolin-3(1H)-ones and 1,4-dimethyl-7-pyridin-3-yl-2-(phenylsulfonylmethyl)-1,4-dihydropyrrolo[4,3,2-de]isoquinoline-3,6-dione were synthesized. Their antiviral activity against influenza A/New Caledonia/20/99 virus (H1N1), bovine viral diarrhea virus (BVDV), and hepatitis C virus (HCV) was studied. The synthesized compounds were not noticeably active against these viruses. The exceptions were only Et 5-hydroxy-4-(dimethylaminomethyl)-1-methyl-6-pyridin-3-yl-2-(phenylsulfinylmethyl)-1H-indole-3-carboxylate and 5-hydroxy-1,2-dimethyl-6-fluoro-1H-indole-3-carboxylate hydrochlorides, which exhibited micromolar activities EC50 = 6.6 and 9.8 iM, resp., against a human hepatoma cell line (Huh7.3) with increased sensitivity to HCV infection (strain JFH-1, genotype 2a). The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Category: piperidines)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem