Ishihara, Tsukasa; Seki, Norio; Hirayama, Fukushi; Orita, Masaya; Koshio, Hiroyuki; Taniuchi, Yuta; Sakai-Moritani, Yumiko; Iwatsuki, Yoshiyuki; Kaku, Seiji; Kawasaki, Tomihisa; Matsumoto, Yuzo; Tsukamoto, Shin-ichi published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors》.HPLC of Formula: 126832-81-3 The author mentioned the following in the article:
We describe here our investigation of a new series of orally active fXa inhibitors based on a prodrug strategy. Solid-phase parallel synthesis identified a unique series of fXa inhibitors with a substituted benzenesulfonyl group as a novel S4 binding element. This series resulted in compound 39 (I), which exhibited potent inhibitory activity against fXa (IC50 = 13 nM) and excellent selectivity over thrombin (>7000-fold). The masking of its highly hydrophilic groups led to the creation of related prodrug 28, which demonstrated an anticoagulant effect after oral dosing. In addition to this study using 1-Pyridin-4-ylpiperidin-4-one, there are many other studies that have used 1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3HPLC of Formula: 126832-81-3) was used in this study.
1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. HPLC of Formula: 126832-81-3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem