Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 22990-77-8, Name is 2-Piperidylmethylamine, SMILES is NCC1NCCCC1, in an article , author is Seo, Jeongseob, once mentioned of 22990-77-8, Category: piperidines.
Benzyne-Induced Ring Opening Reactions of DABCO: Synthesis of 1,4-Disubstituted Piperazines and Piperidines
The 2-(4-phenylpiperazin-1-yl)ethan-1-amine scaffold is a structurally important motif that occurs frequently in medicinal and pharmaceutical chemistry. Despite the significance of this moiety, general strategies for its synthesis to date have required multistep methods and have been very limited, such as the use of SNAr-type reactions. Herein, we describe a synthetic methodology employing benzynes, 1,4-diazabicyclo(2.2.2)octane (DABCO), and nitrogen nucleophiles to access these privileged organic compounds. The established protocol proved to be a transition-metal-free, mild reaction that proceeded via a quaternary ammonium salt formed from the benzyne and DABCO.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 22990-77-8, you can contact me at any time and look forward to more communication. Category: piperidines.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem