Administration of Memantine During Withdrawal Mitigates Overactivity and Spatial Learning Impairments Associated with Neonatal Alcohol Exposure in Rats was written by Idrus, Nirelia M.;McGough, Nancy N. H.;Riley, Edward P.;Thomas, Jennifer D.. And the article was included in Alcoholism: Clinical & Experimental Research in 2014.Safety of 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol This article mentions the following:
Background : Prenatal alc. exposure can disrupt central nervous system development, manifesting as behavioral deficits that include motor, emotional, and cognitive dysfunction. Both clin. and animal studies have reported binge drinking during development to be highly correlated with an increased risk of fetal alc. spectrum disorders (FASD). We hypothesized that binge drinking may be especially damaging because it is associated with episodes of alc. withdrawal. Specifically, we have been investigating the possibility that NMDA receptor-mediated excitotoxicity occurs during alc. withdrawal and contributes to developmental alc.-related neuropathol. Consistent with this hypothesis, administration of the NMDA receptor antagonists MK-801 or eliprodil during withdrawal attenuates behavioral alterations associated with early alc. exposure. In this study, we investigated the effects of memantine, a clin. used NMDA receptor antagonist, on minimizing ethanol-induced overactivity and spatial learning deficits. Methods : Sprague-Dawley pups were exposed to 6.0 g/kg ethanol via intubation on postnatal day (PD) 6, a period of brain development that models late gestation in humans. Controls were intubated with a calorically matched maltose solution During withdrawal, 24 and 36 h after ethanol exposure, subjects were injected with a total of either 0, 20, or 30 mg/kg memantine. The subjects’ locomotor levels were recorded in open field activity monitors on PDs 18 to 21 and on a serial spatial discrimination reversal learning task on PDs 40 to 43. Results : Alc. exposure induced overactivity and impaired performance in spatial learning. Memantine administration significantly attenuated the ethanol-associated behavioral alterations in a dose-dependent manner. Thus, memantine may be neuroprotective when administered during ethanol withdrawal. Conclusions : These data have important implications for the treatment of EtOH’s neurotoxic effects and provide further support that ethanol withdrawal significantly contributes to FASD. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Safety of 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol).
1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Safety of 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem