Hosono, Naoko et al. published their research in Igaku no Ayumi in 2021 | CAS: 1095173-27-5

1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (cas: 1095173-27-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Reference of 1095173-27-5

Molecularly targeted therapy, from the past to the near future was written by Hosono, Naoko. And the article was included in Igaku no Ayumi in 2021.Reference of 1095173-27-5 This article mentions the following:

Mol.-targeted drugs for leukemia have made remarkable progress in recent years. As the gene mutations involved in the development of leukemia and their hierarchical structure have been clarified, the development of low-mol.-weight compounds targeting the mutant genes has also made remarkable progress and in the United States, the hedgehog inhibitor mutant isocitrate dehydrogenase Enzyme (IDH) inhibitor, approval of oral methylation inhibitors has been obtained for acute myeloid leukemia (AML), and approval in Japan is awaited. Clin. trials of promising drugs for refractory leukemia, such as TP53 reactivating drugs and cyclin-dependent kinases, are also underway. Initially, antibody drugs focused only on leukemia tumor cells, but with the success of bispecific T-cell induction (BITE) antibodies in acute lymphocytic leukemia (ALL), leukemia stem cells Development of antibody drugs targeting leukemia and antibody drugs that suppress immune tolerance and induce phagocytosis of macrophages is underway. Leukemia treatment has long been centered on cell-killing antitumor agents, but is now at a turning point with the development of science. This paper outlines the current status and prospects of the development of mol.-targeted drugs for acute leukemia, which is considered to be the hottest topic at present. In the experiment, the researchers used many compounds, for example, 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (cas: 1095173-27-5Reference of 1095173-27-5).

1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (cas: 1095173-27-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Reference of 1095173-27-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem