Synthesis and antihypertensive activity of some new quinazoline derivatives was written by Honkanen, Erkki;Pippuri, Aino;Kairisalo, Pekka;Nore, Pentti;Karppanen, Heikki;Paakkari, Ilari. And the article was included in Journal of Medicinal Chemistry in 1983.Recommanded Product: 1-Benzylpiperidine-4-carbonitrile This article mentions the following:
A series of substituted 2-piperidino-4-amino-6,7-dimethoxyquinazolines I.HCl [R = Me, CH2Ph, CH(OH)R1 (R1 = alkyl, cycloalkyl), COR2 (R2 = alkyl, cycloalkyl, alkoxy, amino)] was synthesized and screened as potential antihypertensive agents. At small doses, two of the new compounds I (R = 4-(cyclopentylcarbonyl), 4-Q], appeared to be somewhat less potent than prazosin,; but at the higher doses of 10-100 μmol/kg, they appeared to be even more efficacious antihypertensive agents than prazosin. Structure activity relationships were discussed. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4Recommanded Product: 1-Benzylpiperidine-4-carbonitrile).
1-Benzylpiperidine-4-carbonitrile (cas: 62718-31-4) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: 1-Benzylpiperidine-4-carbonitrile
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem