In 2022,Holman, Samuel D. L.; Wills, Alfie G.; Fazakerley, Neal J.; Poole, Darren L.; Coe, Diane M.; Berlouis, Leonard A.; Reid, Marc published an article in Chemistry – A European Journal. The title of the article was 《Electrochemical Synthesis of Isoxazolines: Method and Mechanism》.Application In Synthesis of tert-Butyl 4-aminopiperidine-1-carboxylate The author mentioned the following in the article:
An electrochem. method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochem. enabled regio- and diastereoselective reaction with electron-deficient alkenes. Addnl., in-situ reaction monitoring methods compatible with electrochem. equipment have been developed in order to probe the reaction pathway. Supporting analyses from kinetic (time-course) modeling and d. functional theory support a stepwise, radical-mediated mechanism, and discounts hypothesised involvement of closed shell [3+2] cycloaddition pathways. The results came from multiple reactions, including the reaction of tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Application In Synthesis of tert-Butyl 4-aminopiperidine-1-carboxylate)
tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application In Synthesis of tert-Butyl 4-aminopiperidine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem