The 浼?tertiary amine motif drives remarkable selectivity for Pd-catalyzed carbonylation of 灏?methylene C-H bonds was written by Hogg, Kirsten F.;Trowbridge, Aaron;Alvarez-Perez, Andrea;Gaunt, Matthew J.. And the article was included in Chemical Science in 2017.SDS of cas: 33439-27-9 This article mentions the following:
The selective C-H carbonylation of methylene bonds in the presence of traditionally more reactive Me C-H and C(sp2)-H bonds in 浼?tertiary amines was reported. The exceptional selectivity was driven by the bulky 浼?tertiary amine motif, the hypothesis orientates the activating C-H bond proximal to Pd in order to avoid an unfavorable steric clash with a second 浼?tertiary amine on the Pd center, promoting preferential cyclopalladation at the methylene position. The reaction tolerated a range of structurally interesting and synthetically versatile functional groups, delivered the corresponding 灏?lactam products in good to excellent yields. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9SDS of cas: 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.SDS of cas: 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem