The author of 《4-Substituted piperidines. III. Reduction of 1-benzyl-4-cyano-4-tert-aminopiperidines with lithium aluminum hydride》 were Hermans, Bert; van Daele, Paul; van de Westeringh, Cornelis; van der Eycken, Cyriel; Boey, Jozef; Janssen, Paul A. J.. And the article was published in Journal of Medicinal Chemistry in 1966. Safety of 4-Amino-1-benzylpiperidine-4-carbonitrile The author mentioned the following in the article:
cf. CA 63, 16298f. The reduction of 1-benzyl-4-cyano-4-tert-aminopiperidines with LiAlH4 is described; this reduction results in dentrilation, whereas the same reduction of the corresponding primary carboxamides yields the expected primary amines, which can easily be acylated. The obtained compounds are debenzylated, after which other substituents are introduced. These new compounds are virtually devoid of hypotensive or central nervous system depressant activity. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5Safety of 4-Amino-1-benzylpiperidine-4-carbonitrile)
4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of 4-Amino-1-benzylpiperidine-4-carbonitrile
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem