Preparation and quality control of compound cyproheptadine hydrochloride gel was written by He, Mingchao;Wang, Zhongshu. And the article was included in Zhongguo Yaoye in 2006.Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride This article mentions the following:
The gel contained carbomer-940 as the base, triethanolamine as pH adjuster and ethylparaben as preservative. The contents of cyproheptadine hydrochloride (Cph) and dexamethasone acetate (Dxm) in gel were determined by dual-wavelength spectrophotometry and HPLC resp. The gel exhibited fine consistency and moderate viscosity. The average content of Cph in the gel was 101.29% with an average recovery of 101.56% (RSD = 1.90%). The average content of Dxm in the gel was 99.20% with an average recovery of 99.44% (RSD = 2.46%). In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride).
4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem