Proton nuclear magnetic resonance spectroscopy (NMR) methods for determining the purity of reference drug standards and illicit forensic drug seizures was written by Hays, Patrick A.. And the article was included in Journal of Forensic Sciences in 2005.Reference of 2192-20-3 This article mentions the following:
A rapid, sensitive, accurate, precise, reproducible, and versatile method for determining the purity of reference drug standards and the routine anal. of illicit drugs and adulterants using proton (1H) NMR Spectroscopy is presented. The methodol. uses a weighed sample dissolved in a deuterated solvent or solvent mixture containing a high purity internal standard The NMR experiment employs 8 scans using a 45 s delay and 90° pulse. In the determination of purity of reference standards, the number of quant. determinations available is equal to the number of peak groups that are baseline resolved. The relative standard deviation (RSD) of these signals is usually <1% for pure standards, and the results agree well with other purity determining methods. This method can also aid in the determination of correct mol. weight for standards containing an unknown number of waters of hydration or an unknown number of acids per drug in salts. Because the molar response for the hydrogen nucleus is 1 for all compounds, and since no separation media are used, only one linearity study is required to test a probe. In the presented study, the linearity of the NMR probe was determined using methamphetamine HCl dissolved in deuterium oxide (D2O) with maleic acid as the internal standard (5 mg) for a range of concentrations from 0.033 to 69.18 mg/mL with a resulting correlation coefficient of >0.9999 for all 6 methamphetamine peak groups. The spectra of complex illicit heroin, methamphetamine, MDMA, and cocaine samples are presented, as well as an extensive list of compounds, their solubilities and the solvent(s) and internal standard used. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Reference of 2192-20-3).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Reference of 2192-20-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics