Hamper, Bruce C. published the artcileSolid Phase Synthesis of β-Peptoids: N-Substituted β-Aminopropionic Acid Oligomers, Recommanded Product: 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, the main research area is solid phase preparation peptoid combinatorial library; substituted aminopropionic acid oligomer library preparation.
A solid-phase organic synthesis method has been developed for the preparation of N-substituted-β-aminopropionic acid oligomers or β-peptoids I. Treatment of polymer-bound 4-(benzyloxy)benzyl acrylate with primary amines afforded N-substituted β-alanines. Polymer loadings and product conversions were determined by direct cleavage of resin-bound materials and measurement by 1H NMR with an internal standard The NMR method was used to establish loading of all resin-bound intermediates including acrylic acid. Acylation with acryloyl chloride followed by Michael addition of primary amines to the acrylamide allowed preparation of di-β-peptoids. By a linear set of seven reactions, trimeric N-benzyl-β-aminopropionic acid was prepared in 67% overall yield. Single-bead FT-IR microspectroscopy was used to acquire spectra of the resin bound mono-β-peptoids, di-β-peptoids, and acrylamide intermediates. A combinatorial library of defined mixtures of tri-β-peptoids was prepared by mixing equimolar amounts of the mono-β-peptoid resins and carrying them through two sequences of the acylation-Michael addition The identity of a sample mixture II (R = Me, CH2Ph, CH2CH2Ph, CH2C6H4OMe-4, allyl, CH2CHMe2, CHMeEt, CHMe2) was determined by LC-MS anal. of the cleavage product.
Journal of Organic Chemistry published new progress about Combinatorial chemistry. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Recommanded Product: 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem