In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe was written by Ha, Khanh;Zheng, Xiaoxin;Kessinger, Chase W.;Mauskapf, Adam;Li, Wenzhu;Kawamura, Yoichiro;Orii, Makoto;Hilderbrand, Scott A.;Jaffer, Farouc A.;McCarthy, Jason R.. And the article was included in ACS Sensors in 2021.SDS of cas: 142355-83-7 This article mentions the following:
Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biol. activity of this cell type from a basic exptl. focus to a clin. focus, new translatable platelet-specific mol. imaging agents are required. Herein, the development of a near-IR fluorescence probe based upon tirofiban, a clin. approved small-mol. glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa) was reported. Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7SDS of cas: 142355-83-7).
4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem