Guo, Cuiping published the artcileMinimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening, Computed Properties of 73874-95-0, the main research area is proteome profiling cell imaging drug screening linker fluorescent probe.
Activity-based protein profiling (ABPP) and bioimaging have been powerful approaches for in situ drug screening and target identification. However, these approaches are still hindered by the preparation of high-quality probes. To address this challenge, we developed a series of novel minimalist linkers for irreversible inhibitors by incorporation of various bioorthogonal handles into an α,β-unsaturated amide, a common moiety of many irreversible inhibitors. The linker-containing probes have been demonstrated to be suitable for simultaneous protein labeling, live cell imaging and drug screening.
Chemical Communications (Cambridge, United Kingdom) published new progress about Affinity labeling. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Computed Properties of 73874-95-0.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem