Gorski, Bartosz published the artcileCopper-catalysed amination of alkyl iodides enabled by halogen-atom transfer, Synthetic Route of 170364-89-3, the publication is Nature Catalysis (2021), 4(7), 623-630, database is CAplus.
Here, an alternative amination strategy was demonstrated for the synthesis of alkyl amines, e.g., I where alkyl iodides are used as radical precursors instead of electrophiles. Use of α-aminoalkyl radicals enabled the efficient conversion of the iodides into the corresponding alkyl radical by halogen-atom transfer, while copper catalysis assembled the sp3 C-N bonds at room temperature The process provided SN2-like programmability, and application in late-stage functionalization of several densely functionalized pharmaceuticals demonstrated its utility in the preparation of valuable N-alkylated drug analogs.
Nature Catalysis published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H24N2O2, Synthetic Route of 170364-89-3.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem