A synergistic combinatorial and chiroptical study of peptide catalysts for asymmetric Baeyer-Villiger oxidation was written by Giuliano, Michael W.;Lin, Chung-Yon;Romney, David K.;Miller, Scott J.;Anslyn, Eric V.. And the article was included in Advanced Synthesis & Catalysis in 2015.Computed Properties of C21H21NO4 The following contents are mentioned in the article:
We report an approach to the asym. Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a CD-based assay of alcs. derived from the products of solution-phase reactions established the absolute configuration of lactone products; this assay proved equivalent to HPLC in its ability to evaluate catalyst performance, but was far superior in its speed of anal. Further solution-phase screening of a focused library suggested a mode of asym. induction that draws distinct parallels with the mechanism of Baeyer-Villiger monooxygenases. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Computed Properties of C21H21NO4).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Computed Properties of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem