A synergistic combinatorial and chiroptical study of peptide catalysts for asymmetric Baeyer-Villiger oxidation was written by Giuliano, Michael W.;Lin, Chung-Yon;Romney, David K.;Miller, Scott J.;Anslyn, Eric V.. And the article was included in Advanced Synthesis & Catalysis in 2015.Application of 86069-86-5 The following contents are mentioned in the article:
We report an approach to the asym. Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a CD-based assay of alcs. derived from the products of solution-phase reactions established the absolute configuration of lactone products; this assay proved equivalent to HPLC in its ability to evaluate catalyst performance, but was far superior in its speed of anal. Further solution-phase screening of a focused library suggested a mode of asym. induction that draws distinct parallels with the mechanism of Baeyer-Villiger monooxygenases. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Application of 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Application of 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem