Gitto, Rosaria; De Luca, Laura; Mancuso, Francesca; Del Prete, Sonia; Vullo, Daniela; Supuran, Claudiu T.; Capasso, Clemente published an article in 2019, the title of the article was Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:
A series of sixteen benzenesulfonamide derivatives has been synthesized and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship anal. highlighted that all tested compounds proved to be active inhibitors of VchCAα at nanomolar concentration The VchCAβ activity was lower to respect inhibitory efficacy toward VchCAα, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAγ. Interestingly, compound combined the best activity toward VchCAα and VchCAβ. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAβ. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to benzene sulfonamide derivative preparation carbonic anhydrase inhibitor cholera, carbonic anhydrase inhibitors (cais), benzenesulfonamides, molecular docking, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol
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